Tuberculosis treatment raises total cholesterol level and restores high density lipoprotein cholesterol (HDL-C) in patients with pulmonary tuberculosis

AKPOVI Dewanou Casimir, GBAGUIDI Lucette H. Senami, ANAGO Eugénie, AFFOLABI Dissou, DOUGNON Tamègnon Victorien, FAIHUN Franck, and ANAGONOU Sévérin

Accepted 16 September, 2013

Abstract 
The aim of this study was to determine whether tuberculosis (TB) treatment normalizes the lipid profile
strongly affected by pulmonary TB. Serum levels of total cholesterol (TC), high density lipoprotein
cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and triglycerides (TG) were determined
in 83 patients with pulmonary TB before and after treatment, and compared to results obtained from 100
control subjects without TB. Before treatment, levels of TC (p<0.005), HDL-C (p<0.005) and LDL-C
(p<0.005) were significantly lower in pulmonary TB patients than normal subjects. Unlike TC and LDL-C,
HDL-C decrease was correlated (r = 0.96, p<0.05) with smear positivity extent (SPE). At the end of TB
treatment, which lasted six months, TC (p<0.01) and HDL-C (p<0.005) levels were significantly increased
than before treatment while LDL-C stayed relatively unchanged. The treatment significantly reduced the
atherogenic indices TC/HDL-C (p<0.001), LDL-C/HDL-C (p<0.001) and log (TG/HDL-C) (p<0.001) levels.
Our results show that tuberculosis treatment increases TC levels and normalizes HDL while reducing
atherogenic indices to below levels of controls.

Key words: Pulmonary tuberculosis, lipid profile, treatment, atherogenic index.

1 réflexion sur “Tuberculosis treatment raises total cholesterol level and restores high density lipoprotein cholesterol (HDL-C) in patients with pulmonary tuberculosis”

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